Red-Plus

Description

Each Red Plus timed release capsule contains 150 mg of dried Ferrous Sulphate BP equivalent to 47mg Iron, 500mcg Folic Acid BP and 61.8 mg of Zinc Sulphate Monohydrate USP equivalent to 22.5 mg zinc. It is a clear, transparent capsule filled with a mixture of red, pale yellow, pink and white pellets. This capsule is especially formulated for extended release of iron over a period of several hours and that of zinc over one to two hours.

Indications

Red Plus is an oral iron, folic acid and zinc preparation indicated for the treatment of iron, folic acid and zinc deficiency. Red Plus is indicated on prophylaxis of iron deficiency especially when inadequate diet calls for supplementary zinc and iron during pregnancy. Dosage and administration

Prophylaxis Adult:

One capsule a day. In more severe cases, two capsules a day may be required as prescribed by the physician. Elderly: Dosage as above. Children aged over 1 year: One capsule a day, the capsule may be opened and the pellets mixed with soft cool food but they must not be chewed. Treatment: 2 to 4 capsules a day as prescribed by the physician.

Contraindication

It is contraindicated in patients with haemolytic anaemia and in conditions with increased hypersensitivity to any of its components and increased body iron content.

Use in pregnancy

Administration in first trimester of pregnancy should be avoided unless definite evidence of iron deficiency is observed. Prophylaxis of iron deficiency is justified during the remainder of pregnancy specifically when zinc supplementation is required.

Side effects

Side effects of iron, folic acid and zinc supplementation are mild and transient. These include epigastric pain, nausea, constipation, vomiting, diarrhoea etc. The blended Red Plus capsule is especially designed to reduce the possibility of gastrointestinal irritation.

Drug interactions

Iron chelates with tetracycline.Since oal iron produts interfere with absorption of oral tetracycline antibiotics, these product should not be taken within two hours of each other. Occasional gastrointestinal discomfort may be minimized by taking with meals. Absorption of iron may be impaired by concurrent administrations of penicillamine and antacid. In patients with renal failure, a risk of zinc accumulation may exist.

Overdose

Overdose of iron is dangerous, particularly in children and requires immediate attention. Gastric lavage should be carried out in the early stages, vomiting may also be induced. Zinc sulfate in gross overdosage is corrosive. Symptoms are those of gastrointestinal irritation, leading in severe cases to haemorrhagic corrosion of the mucosa and possible later stricture formation. Demulcents such as milk should be given. Chelating agents such as dimercaprol, penicillamine or edetic acid have been recommended. The extended release capsule presentation may delay excessive absorption of iron and zinc and allow more time for initiation of appropriate counter measures.

Precautions

Care should be taken in patients who may develop iron overload, such as those with haemochromatosis, haemolytic anaemia or red cell aplasia. Failure to respond to treatment may indicate other causes of anaemia and should be further invstigated

Pharmaceutical Precautions

Store in a dry place below 250 C and protect from sunlight. Keep out of the reach of children.

Commercial pack

Box containing 100 capsules in 10X10’s blister strips. Each capsule contains Dried Ferrous Sulphate BP 150 mg equivalent to Iron 47 mg, Folic Acid BP 500 mcg and Zinc Sulfate Monohydratre USP 61.8 mg equivalent to Zinc 22.5 mg.

Manufactured by :

Ad-Din Pharmaceuticals Ltd.