COMPOSITION Sugred Tablet: Each tablet contains Gliclazide BP 80 mg. INDICATIONS Sugred Tablet is indicated for the treatment of type 2 diabetes in association with dietary measures when dietary measures alone are inadequate to control blood glucose. DOSAGE AND ADMINISTRATION The usual initial dose of Sugred is 40 to 80 mg daily, gradually increased, if necessary up to 320 mg daily until adequate control is achieved. A single dose should not exceed 160 mg. When higher doses are required it should be taken twice daily, according to the main meals of the day. CONTRAINDICATIONS Gliclazide (Sugred) should not be used in juvenile onset diabetes, diabetes complicated by ketosis and acidosis, diabetes undergoing surgery, after severe trauma or during infections, patients known to have hypersensitivity to other sulfonylurea and related drugs, diabetic pre-coma & coma, severe renal or hepatic insufficiency, combination with miconazole tablets. SIDE EFFECTS Hypoglycemia may occur in concurrent conditions such as hepatic & renal diseases, alcohol intoxication and adrenal and pituitary insufficiency. Mild gastro-intestinal disturbances including nausea, dyspepsia, diarrhea, and constipation have been reported but these types of adverse reactions can be avoided if Gliclazide (Sugred) is taken during a meal. Allergic dermatological reactions including rash, pruritis, erythema, bulbous eruption have been reported during treatment with the drug but are not known to be directly attributable to it. DRUG INTERACTION The hypoglycemic effect of Gliclazide may be potentiated by NSAID (in particular aspirin), phenylbutazone, sulfonamide, coumarin derivatives, MAIOs, beta-adrenergic blockers, tetracyclines, chloramphenicol, clofibrate, cimetidine and miconazole tablets. Ingestion of alcohol may also increase the hypoglycemic effect of Gliclazide (Sugred). Some drugs may on the contrary, reduce its activity e.g. barbiturates, corticosteroids, thiazide diuretics, thyroid hormones, laxatives and oral contraceptives. USE IN PREGNANCY AND LACTATION During Pregnancy: Gliclazide (Sugred) should not be used in pregnancy. Nursing Mothers: No study has reported its presence in human breast milk. However other sulfonylureas have been found in milk and there is no evidence to suggest that Gliclazide (Sugred) differs from the group in this respect. STORAGE PRECAUTIONS Store at a cool & dry place, protect from light & moisture. Keep out of the reach of children. COMMERCIAL PACK Sugred Tablet: Box containing 5 X 10’s tablets in blister pack.. Manufactured by: Ad-Din Pharmaceuticals Ltd.